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1-Acetyl-N,N-diethyllysergamide ( ALD-52, 1-Acetyl-LSD, 1A-LSD, 1A-LAD) is a lesser-known psychedelic substance of the lysergamide class.Also, produces LSD-like psychedelic effects when administered. It is structurally related to psychedelic lysergamides like LSD and 1P-LSD. Thus, it produces largely indistinguishable effects.

ALD-52 was originally discovered by Albert Hofmann in his study of LSD analogs. However, it did not enter mainstream awareness until the 1960s Western youth counterculture.

Alexander Shulgin touches briefly on the subject of ALD-52 in the commentary section of LSD-25 in the book TiHKAL. His writings state that doses in the 50-175 µg range result in various effects similar to LSD. His reports indicate that it produces less visual distortion than with LSD.Also he stated less anxiety and tenseness and less potent than LSD. Another report found the two substances to be indistinguishable.


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